Blar i ODA Open Digital Archive på forfatter "Llorente, Alicia"

Viser treff 1-12 av 12

    • Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges 

      Skotland, Tore; Iversen, Tore Geir; Llorente, Alicia; Sandvig, Kirsten (Advanced Drug Delivery Reviews;Volume 186, July 2022, 114326, Peer reviewed; Journal article, 2022-05-21)
      There is a large interest in developing nanoparticles and extracellular vesicles for delivery of therapeutics or imaging agents. Regulatory approval of such products requires knowledge about their biodistribution, metabolism ...

    • Ebulin l Is Internalized in Cells by Both Clathrin-Dependent and -Independent Mechanisms and Does Not Require Clathrin or Dynamin for Intoxication 

      Iglesias, Rosario; Ferreras, José M; Llorente, Alicia; Citores, Lucía (Toxins;Volume 13 / Issue 2, Peer reviewed; Journal article, 2021-01-30)
      Ebulin l is an A-B toxin, and despite the presence of a B chain, this toxin displays much less toxicity to cells than the potent A-B toxin ricin. Here, we studied the binding, mechanisms of endocytosis, and intracellular ...

    • The expanding organelle lipidomes: current knowledge and challenges 

      Sarmento, Maria J.; Llorente, Alicia; Petan, Toni; Khnykin, Denis; Popa, Iuliana; Nikolac Perkovic, Matea; Konjevod, Marcela; Jaganjac, Morana (Peer reviewed; Journal article, 2023)
      Lipids in cell membranes and subcellular compartments play essential roles in numerous cellular processes, such as energy production, cell signaling and inflammation. A specific organelle lipidome is characterized by lipid ...

    • Extracellular vesicles and renal fibrosis: An odyssey toward a new therapeutic approach 

      Kosanovic, Maja; Llorente, Alicia; Glamočlija, Sofija; Valdivielso, Jose M.; Bozic, Milica (International Journal of Molecular Sciences;Volume 22, Issue 8, Peer reviewed; Journal article, 2021-04-09)
      Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells ...

    • Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research 

      Ramirez-Garrastacho, Manuel; Bajo-Santos, Cristina; Line, Aija; Martens-Uzunova, Elena S.; de la Fuente, Jesus Martinez; Moros, Maria; Soekmadji, Carolina; Tasken, Kristin Austlid; Llorente, Alicia (British Journal of Cancer;126 (2022), Peer reviewed; Journal article, 2021-11-22)
      Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Approximately a decade ago, the potential of analysing extracellular vesicles in ...

    • Extracellular Vesicles as Novel Players in Kidney Disease 

      Blijdorp, Charles J.; Burger, Dylan; Llorente, Alicia; Martens-Uzunova, Elena S.; Erdbrügger, Uta (Journal of the American Society of Nephrology;Vol. 33, Issue 3, Peer reviewed; Journal article, 2022-02-28)
      “Urine can provide us day by day, month by month, and year by year with a serial story of the major events within the kidney.” Dr. Thomas Addis, pioneer in renal physiology, came to this conclusion in 1948. The discovery ...

    • Implication of β2-adrenergic receptor and miR-196a correlation in neurite outgrowth of LNCaP prostate cancer cells 

      Guerriero, Ilaria; Ramberg, Håkon Andre; Sagini, Krizia; Ramirez-Garrastacho, Manuel; Tasken, Kristin Austlid; Llorente, Alicia (PLOS ONE;16 (6): e0253828, Peer reviewed; Journal article, 2021-06-30)
      The β2-adrenergic receptor has been shown to be involved in neuroendocrine differentiation and to contribute to the development of aggressive prostate cancer. In this study we have investigated whether miR-196a plays a ...

    • Lipid Biomarkers in Liquid Biopsies: Novel Opportunities for Cancer Diagnosis 

      Sagini, Krizia; Urbanelli, Lorena; Buratta, Sandra; Emiliani, Carla; Llorente, Alicia (Peer reviewed; Journal article, 2023)
      Altered cellular metabolism is a well-established hallmark of cancer. Although most studies have focused on the metabolism of glucose and glutamine, the upregulation of lipid metabolism is also frequent in cells undergoing ...

    • Plasma and urinary extracellular vesicles as a source of RNA biomarkers for prostate cancer in liquid biopsies 

      Bajo-Santos, Cristina; Brokāne, Agnese; Zayakin, Pawel; Endzeliņš, Edgars; Soboļevska, Kristīne; Belovs, Alberts; Jansons, Juris; Sperga, Māris; Llorente, Alicia; Radoviča-Spalviņa, Ilze; Lietuvietis, Vilnis; Linē, Aija (Peer reviewed; Journal article, 2023)
      Introduction: Extracellular vesicles (EVs) have emerged as a very attractive source of cancer- derived RNA biomarkers for the early detection, prognosis and monitoring of various cancers, including prostate cancer (PC). ...

    • Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients 

      Ramirez-Garrastacho, Manuel; Berge, Viktor; Linē, Aija; Llorente, Alicia (British Journal of Cancer;126 (2022), Peer reviewed; Journal article, 2021-11-22)
      Background: Active surveillance is an alternative to radical treatment for patients with low-risk prostate cancer, which could also benefit some patients with intermediate risk. We have investigated the use of miRNA in ...

    • siRNA screening reveals that SNAP29 contributes to exosome release 

      Hessvik, Nina Pettersen; Sagini, Krizia; Romero, Silvana Angelica Troncoso; Ramirez, Manuel; Rodriguez, Marta; Tutturen, Astrid Elisabeth Voorham; Kvalvaag, Audun Sverre Myrset; Stang, Espen; Brech, Andreas; Sandvig, Kirsten; Llorente, Alicia (Peer reviewed; Journal article, 2023)
      Cells release extracellular vesicles (EVs) of different sizes. Small EVs (< 200 nm) can originate from the fusion of multive- sicular bodies with the plasma membrane, i.e. exosomes, and from budding of the plasma membrane, ...

    • Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles 

      Llorente, Alicia; Erdbrügger, Uta; Blijdorp, Charles J; Martens-Uzunova, Elena S. (Journal of Extracellular Vesicles;Volume 10, Issue 7. May 2021 - e12093, Peer reviewed; Journal article, 2021-05-21)
      Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles ...